抗DXd抗体

产品名称	Mouse Anti DXd Antibody, mAb
靶点	DXd
类型	Monoclonal
产品货号	DTA0031
产品规格
价格

产品详情

浓度	0.5 mg/mL
免疫宿主	Mouse
免疫原	DXd conjugated to keyhole limpet haemocyanin(KLH)
克隆号	1M2F3
亚型	IgG1
纯化方法	Purified by Protein A
特异性	This antibody recognizes DXd and DXd structurally similar molecules. The antibody can bind to DS-8201.
验证应用平台	ELISA
缓冲液	1×PBS, pH7.4, containing 0.05% BSA, 50% glycerol and 0.03% Proclin 300.
储存方式	Shipped in ice bag. The antibody can be stored for 1-2 weeks at 2-8°C. For long term storage, store it at -20°C. Avoid repeated freezing and thawing cycles.

产品应用

应用	ELISA
推荐用量	0.00005-1 µg/mL

生物活性-ELISA

Anti-DXd

The DXd conjugated Trastuzumab ELISA assay is developed by using Mouse Anti DXd Antibody, mAb (Cat:DTA0031) and Goat Anti Mouse IgG Antibody[HRP], mAb as the capture and detection antibodies.

	DTA0031
EC50	9.507 ng/mL

Mouse Anti DXd Antibody, mAb (Cat:DTA0031) binds with DS-8201.
Coating antigen: DS-8201, 0.1 µg
Mouse Anti DXd Antibody, mAb (Cat:DTA0031) dilution start from 1000 ng/mL.

产品说明书产品说明书

DXd is a derivative of exatecan (DX8951f), a compound with increased activity and improved solubility compared to CPT, and described not to be an ABCC2 or ABCG1 substrate. DXd was used in several proprietary ADC programs, such as DS-8201a (Enhertu), U3-1402 and DS-6157a, conjugated at DAR8 and DS-1062a and DS-7300a conjugated at lower DAR (4) to limit their toxicity, that are either approved by the FDA (DS-8201a) or currently under clinical evaluation. Although the DXd payload presented lower passive membrane permeability than exatecan mesylate, it was found to be less myelotoxic and was therefore also selected for its improved safety profile.
The anti-payload antibody is a useful reagent in ADC research by quantifying and monitoring drug levels or accumulations in tumor tissue, and more. It can be used in PK, PD analysis and ELISA.

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发货时间：确认订单并完成付款后1~2个工作日内安排发货。
发货方式：冰袋或干冰。